Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Here’s just a repost of an abstract on a “new” lipid force-field. One maybe should better say a new derivative force-field, or a modified existing force-field to be more accurate. What’s most interesting is the claim that a fully quantum mechanics based parametrization results in properties acceptably close to experimental values.

Researchers at Yale, using what they call “DFT augmented retrosynthesis” reduce to one third the steps needed to synthesize paspaline A. They synthesize it in 9 steps. They also provide a route for the first synthesis of emindole PB in 13 steps. This is done at Timothy Newhouse’s lab. now at Yale University. Newhouse was a post-doc with E. J. Corey who won the Nobel prize in chemistry in 1990 for his development of retrosynthesis.

I am a bit embarrassed to confess how long I have been using pymol for. It’s certainly been quite a long time, somewhere around ten years. In those years I’ve compiled my own cheat-sheet, which I have abandoned somewhat. Now I’m giving a go to markdown and translating my old cheat sheet into a new one but with the same old tricks.

We are meeting once a week to do a fast review of the GPCR literature. I have selected to review the Journal of Molecular Biology (JMB), and Cell Journal.

This blog will deal with RNA, DNA, and G-Protein Coupled Receptors (GPCR’s) in all of the dimensions known to its author.

This is an old post already from 2015 which I wrote elsewhere and which I’m copying here to test the usage of my new markdown based blogging solution.

Structure of Yeast Argonaute with Guide RNA
Kotaro Nakanishi, David E. Weinberg, David P. Bartel, Dinshaw J. Patel
Nature (2012), 486, 368-373

The Crystal Structure of Human Argonaute2
Nicole T. Schirle and Ian J. Macrae
Science (2012), 336, 1037